What is the name of a bacteria infecting virus

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Rossmann's group has been involved for many years with analysing different viruses and a significant part of their research is dedicated to the bacterial virus T4 that belongs to the Myoviridae family Ackermann, Tail contraction is an essential phase of cellular infection by these phages, resulting in pressing the central tail tube through the outer cell membrane similar to a syringe, thereby creating a channel for DNA ejection from the capsid and into the host cell Figure 1 ; Leiman et al , Bacteriophage T4.

The left panel illustrates the phage in the extended state, whereas the right panel shows the phage in the contracted state. The middle panel shows enlarged fragments of the tail both in extended and contracted states; the upper part of the middle panel demonstrates the fitting of the X-ray structure into EM map. Subunits shadowed in red show their rearrangement in the same helical strand adapted from figures kindly provided by Petr Leiman and Michael Rossmann.

Tailed dsDNA phages are characterised by their futility for crystallisation trials, although crystal structures of some individual protein components have been determined for T4 bacteriophage by the Rossmann lab. Structural studies of other phages from the Myoviridae family were hampered by variation and diversity in the amino-acid sequences among the tailed bacteriophages, making prediction of the structural organisation of phage elements unreliable.

Combining EM and crystallography also allowed the identification of the T4 bacteriophage baseplate proteins, long and short fibres as well as the capsid protein Leiman et al , ; Kostyuchenko et al , The new work by Aksyuk and co-authors published in this issue of The EMBO Journal further advances our understanding of this complex biological system.

Using a similar hybrid approach, Aksyuk et al solve here the crystal structure of a small protease-resistant fragment gp18PR of the sheath protein gp Using molecular replacement, they further determine the structure of the larger gp18M protein comprising three of the four domains of the protein. What is C.

Minus Related Pages. On This Page. Risk Factors for C. Can I get C. Fact Sheet About C. Media Contacts Maria C. Zacharias, NSF, , email: mzachari nsf.

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